Trials within Cohorts (TwiCs) embed one or more randomised controlled trials within cohorts.
The term ‘TwiCs’ was created for the first symposium on the ‘cohort multiple RCT’ design.
This approach to trial design (the cmRCT design) was first described in the BMJ in 2010 article in the context of healthcare.
Key features of the cmRCT design are:
(I) A large observational cohort of people with the condition
(II) Regular measurement of outcomes for the whole cohort
(III) Capacity for multiple randomised controlled trials over time
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